Medical spike

Vitamin D for Darier Disease

Vitamin D for Darier Disease ; Role and Case study

Vitamin D, often known as the “sunshine vitamin”, has proven itself to be a true multitasker, offering a range of benefits beyond what we often hear about. 

One of its lesser-known yet promising roles is in the management of Darier Disease, a skin condition that can significantly impact one’s quality of life. 

In this article, we’ll explore how Vitamin D, with its diverse clinical applications, can be valuable in addressing Darier Disease.

Let’s uncover what happens in this disease and how this vitamin works therapeutically in it.

Anomalies in Darier Disease:

This disease is rooted in a genetic alteration within the ATP2A2 gene, which is responsible for coding the protein known as sarcoplasmic/endoplasmic reticulum Ca2+-ATP isoform 2 (SERCA2). 

This gene resides on chromosome 12q23 and plays a crucial role in cell adhesion processes. When this cellular adhesion mechanism malfunctions, it manifests clinically through distinct skin irregularities recognized as keratotic papules.

Role of vitamin D in Darier disease:

Vitamin D analogs (especially Tacalcitol) exhibit a notable capacity to effectively inhibit the hyperproliferation of keratinocytes, the primary culprits behind the characteristic skin abnormalities in Darier Disease. 

Moreover, a study reports that vitamin D3 analog Tacalcitol, by acting as regulators of epidermal differentiation, ensures that skin cells develop in a controlled and structured manner, contributing to overall skin health restoration.

Moreover, the therapeutic potential of these analogs extends to their anti-inflammatory properties. This anti-inflammatory action aids in alleviating the cutaneous inflammation associated with Darier Disease, offering symptomatic relief and further enhancing the efficacy of treatment strategies

Case Report of Vitamin D for Darier disease: 

In a case report, a 39-year-old female patient developed skin lesions on both sides of her neck, a condition that had initially emerged during the preceding summer and exacerbated with sun exposure. 

Previous medical consultations had led to a diagnosis of chronic eczema, and the patient had undergone a six-month treatment regimen involving topical ointments containing corticosteroids combined with keratolytic agents, such as urea, at other healthcare facilities. 

Unfortunately, her skin lesions remained resistant to this therapy.

Upon physical examination, they observed slightly reddish keratotic small papules specifically on both sides of her neck. Histological examination results aligned with classic features of Darier’s disease, including orthokeratotic hyperkeratosis with mild acanthosis, suprabasal cell acantholysis.

The patient began the topical application of high-concentration vitamin D3 Tacalcitol lotion and was advised to use liquid sunscreen during the daytime. Over the course of five months, there was substantial improvement in her skin lesions. As of the present, her condition remains well controlled, marking a successful intervention in managing localized Darier’s disease.

Vitamin A vs vitamin D in Darier disease: 

Studies have reported the benefits of Vitamin A in darier disease.

But when we have to compare both these vitamins then we’ll look upon them differently. An evaluation of antiproliferative efficiency, as determined by IC 50 values, revealed distinct rankings among various compounds:


This form of Vitamin D exhibited the highest efficiency in inhibiting proliferation.

Ergocalciferol and all-trans Retinoic Acid: 

These substances demonstrated moderate efficiency in their antiproliferative effects.

13-cis Retinoic Acid: 

In comparison, 13-cis Retinoic Acid displayed a relatively lower efficiency in restraining proliferation.

Notably, the research findings suggest that Vitamin D, specifically in the form of cholecalciferol, emerges as a more potent and efficient option for addressing Darier’s disease when contrasted with Vitamin A. 

This insight can guide healthcare professionals and patients alike in making informed decisions regarding treatment strategies.

Top 11 Sources of Vitamin D for Darier Disease Alleviation:

While treatment options have traditionally focused on symptom management, emerging research suggests that incorporating vitamin D sources into one’s diet can offer potential benefits for Darier Disease. 

By including these vitamin D-rich sources in your diet, you can alleviate the symptoms of Darier Disease:

  • Sunlight
  • Fatty Fish
  • Cod Liver Oil
  • Egg Yolks
  • Fortified Foods
  • Mushrooms
  • Cheese
  • Beef Liver
  • Sardines
  • Yogurt
  • Tofu

Also read: Foods to be avoided in Darier disease

Other benefits of vitamin D:

Vitamin D provides a multitude of health benefits beyond its role in Darier disease. One of its crucial functions is maintaining bone health and in the treatment of rickets. 

Emerging research suggests that adequate vitamin D levels are associated with improved mood and a reduced risk of depression and mood disorders, highlighting its importance in mental health.

Furthermore, vitamin D contributes to heart health by supporting cardiac function and regulating blood pressure, potentially reducing the risk of cardiovascular diseases. 

Some studies even suggest that sufficient vitamin D levels may lower the risk of specific cancers, such as breast, prostate, and colon cancer. In addition, vitamin D plays a role in managing autoimmune diseases.


In conclusion, the role of vitamin D presents a promising avenue for management of Darier disease. However, it’s important to note that further research is needed to fully understand the extent of vitamin D’s effectiveness in managing Darier disease and to establish standardized treatment protocols.

Share :

Scroll to Top